Search results for "functionalized microgels and nanogels"

Radiation engineered nanogels as platforms for medical diagnostics and therapeutic nanodevices

2015

A scalable, single step, synthetic approach for the manufacture of biocompatible, functionalized microgels and nanogels has been developed. Pulsed EB irradiation of PVP aqueous solutions, at relatively low energies per pulse and doses within the sterilization dose range, has led to a variety of ‘as-born’ sterile, functional nanostructures that exhibit a combination of favourable properties which make them suitable as biomedical nanocarriers. Reactive functional groups have been generated by graft copolymerization of functional acrylic monomers. These groups can be used to attach fluorescent probes to the NPs, to bioconjugate ligands of specific cell receptors and to incorporate therapeutics…